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Ξ-Defensin 2
ββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββ
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Contents
β’ Eigenschaften
β’ Weblinks
β’ Einzelnachweise
ββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββββ
Eigenschaften
Als Defensin ist Ξ²-Defensin ein antimikrobielles Peptid, das im Zuge der Immunantwort verstΓ€rkt gebildet wird. Ξ²-Defensin wird von Neutrophilen und Epithelzellen in der Haut und den Atemwegen gebildet. Es wirkt gegen Pilze der Gattung Candida und Gram-negative Bakterien.cite-ref-2[2] Ξ²-Defensin bindet an CCR6 und lΓΆst in den CCR6-tragenden Zellen eine Chemotaxis aus. Unterhalb einer Konzentration von 2,4 mM liegt es als Monomer vor.cite-ref-3[3]
Weblinks
Einzelnachweise
cite-note-22. β J. M. SchrΓΆder, J. Harder: Human beta-defensin-2. In: The international journal of biochemistry & cell biology. Band 31, Nummer 6, Juni 1999, S. 645β651, PMID 10404637.
cite-note-33. β M. V. Sawai, H. P. Jia, L. Liu, V. Aseyev, J. M. Wiencek, P. B. McCray, T. Ganz, W. R. Kearney, B. F. Tack: The NMR structure of human beta-defensin-2 reveals a novel alpha-helical segment. In: Biochemistry. Band 40, Nummer 13, April 2001, S. 3810β3816, PMID 11300761.